InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgb6

Summary

InnateDB Protein

IDBP-173470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb6

Protein Name

integrin beta 6

Synonyms

2210409C20Rik; 4831415H04Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028348

InnateDB Gene

IDBG-173466 (Itgb6)

Protein Structure

UniProt Annotation

Function

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding

Biological Process

GO:0006954	inflammatory response
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development

Cellular Component

GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96615

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References