InnateDB Protein
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IDBP-173755.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ncaph2
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Protein Name
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non-SMC condensin II complex, subunit H2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000074139
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InnateDB Gene
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IDBG-173751 (Ncaph2)
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Protein Structure
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Function |
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. Seems to have lineage-specific role in T-cell development. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
Note=Defects in Ncaph2 are the cause of the nessy phenotype which is characterized by a specific defect in T-cell development. Nessy thymuses are smaller, with corticomedullary junctions less well defined, and cortical cells sparser than in wild-type. The thymocyte defect is typified by an increased proportion of CD4-CD8- DN T-cell progenitors. Only thymocyte differentiation is affected in Nessy mice and not cell differentiation.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1289164
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InterPro |
IPR009378
Non-SMC condensin II complex, subunit H2-like
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PFAM |
PF06278
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BSP2
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PhosphoSite |
PhosphoSite-Q8BSP2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
52683
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UniGene |
Mm.488776
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RefSeq |
NP_001108604
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MGI ID |
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MGI Symbol |
Ncaph2
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OMIM |
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CCDS |
CCDS49700
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HPRD |
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IMGT |
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EMBL |
AK004160
AK031135
AK037175
AK080447
AK085584
AK088294
AK146642
AK152158
AK163958
AK165250
BC003900
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GenPept |
AAH03900
BAB23198
BAC27270
BAC29736
BAC37919
BAC39479
BAC40265
BAE27325
BAE30993
BAE37553
BAE38104
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