Version 5.4
Mus musculus Protein: Ncaph2
Summary
InnateDB Protein IDBP-173755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncaph2
Protein Name non-SMC condensin II complex, subunit H2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074139
InnateDB Gene IDBG-173751 (Ncaph2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. Seems to have lineage-specific role in T-cell development. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations Note=Defects in Ncaph2 are the cause of the nessy phenotype which is characterized by a specific defect in T-cell development. Nessy thymuses are smaller, with corticomedullary junctions less well defined, and cortical cells sparser than in wild-type. The thymocyte defect is typified by an increased proportion of CD4-CD8- DN T-cell progenitors. Only thymocyte differentiation is affected in Nessy mice and not cell differentiation.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030261 chromosome condensation
GO:0033077 T cell differentiation in thymus
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1289164
InterPro IPR009378 Non-SMC condensin II complex, subunit H2-like
PFAM PF06278
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BSP2
PhosphoSite PhosphoSite-Q8BSP2
TrEMBL
UniProt Splice Variant
Entrez Gene 52683
UniGene Mm.488776
RefSeq NP_001108604
MGI ID
MGI Symbol Ncaph2
OMIM
CCDS CCDS49700
HPRD
IMGT
EMBL AK004160 AK031135 AK037175 AK080447 AK085584 AK088294 AK146642 AK152158 AK163958 AK165250 BC003900
GenPept AAH03900 BAB23198 BAC27270 BAC29736 BAC37919 BAC39479 BAC40265 BAE27325 BAE30993 BAE37553 BAE38104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca