InnateDB Protein
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IDBP-174255.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pnoc
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Protein Name
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prepronociceptin
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Synonyms
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N/OFQ; N23K; Npnc1; OFQ/N;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000054210
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InnateDB Gene
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IDBG-174253 (Pnoc)
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Protein Structure
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Function |
Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. When administered intracerebroventricularly, nociceptin induces hyperalgesia and decreases locomotor activity.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Brain and spinal cord. Low levels in kidney and spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:105308
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InterPro |
IPR002367
Nociceptin
IPR006024
Opioid neuropeptide precursor
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PFAM |
PF01160
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PRINTS |
PR01031
PR01028
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q64387
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PhosphoSite |
PhosphoSite-Q64387
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TrEMBL |
Q99NQ2
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UniProt Splice Variant |
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Entrez Gene |
18155
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UniGene |
Mm.486163
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RefSeq |
NP_035062
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MGI ID |
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MGI Symbol |
Pnoc
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OMIM |
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CCDS |
CCDS27213
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HPRD |
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IMGT |
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EMBL |
AK045893
AY011825
BC119372
D50055
D50056
D82866
KF006993
U44027
X97371
X97372
X97373
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GenPept |
AAC52581
AAG38274
AAI19373
AGT80622
BAA08773
BAA08774
BAA11614
BAC32523
CAA66041
CAA66042
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