InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esco2

Summary

InnateDB Protein

IDBP-174585.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esco2

Protein Name

establishment of cohesion 1 homolog 2 (S. cerevisiae)

Synonyms

2410004I17Rik; D030072L07Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022613

InnateDB Gene

IDBG-174583 (Esco2)

Protein Structure

UniProt Annotation

Function

Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004468	lysine N-acetyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006275	regulation of DNA replication
GO:0006302	double-strand break repair
GO:0007049	cell cycle
GO:0007059	chromosome segregation
GO:0034421	post-translational protein acetylation
GO:0071168	protein localization to chromatin

Cellular Component

GO:0000785	chromatin
GO:0001741	XY body
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0010369	chromocenter
GO:0031618	nuclear centromeric heterochromatin
GO:0035861	site of double-strand break