Version 5.4
Mus musculus Protein: Siva1
Summary
InnateDB Protein IDBP-174591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siva1
Protein Name SIVA1, apoptosis-inducing factor
Synonyms CD27bp; Siva;
Species Mus musculus
Ensembl Protein ENSMUSP00000021728
InnateDB Gene IDBG-174589 (Siva1)
Protein Structure
UniProt Annotation
Function Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus {ECO:0000250}. Note=In the nucleus, accumulates in dot-like structures. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005175 CD27 receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0009615 response to virus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1353606
InterPro IPR022773 Siva
PFAM PF05458
PRINTS
PIRSF PIRSF038096
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54926
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 30954
UniGene Mm.407012
RefSeq NP_038957
MGI ID
MGI Symbol Siva1
OMIM
CCDS CCDS26193
HPRD
IMGT
EMBL AF033112 AF033113 AF033114 AF033115 AK010562 AK017570 AK153115 BC012279
GenPept AAC04706 AAD50058 AAD50059 AAD50060 AAH12279 BAB27029 BAB30811 BAE31732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca