Version 5.4
Mus musculus Gene: Siva1
Summary
InnateDB Gene IDBG-174589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siva1
Gene Name SIVA1, apoptosis-inducing factor
Synonyms CD27bp; Siva
Species Mus musculus
Ensembl Gene ENSMUSG00000064326
Encoded Proteins
IDBP-174591
SIVA1, apoptosis-inducing factor
IDBP-261715
SIVA1, apoptosis-inducing factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19584092
[Homo sapiens] SIVA1 diminishes NFkappaB and enhances JNK activity to favour apoptosis by physically interacting with MAP3K7 (TAK1) and XIAP.
PMID 19392652
[Homo sapiens] SIVA1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR-mediated activation of NF-kappaB.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184990:
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112644828-112649152
Strand Forward strand
Band F1
Transcripts
ENSMUST00000021728 ENSMUSP00000021728
ENSMUST00000109755 ENSMUSP00000105377
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005175 CD27 receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0009615 response to virus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000184990
View Gene Order
Cross-References
SwissProt O54926
TrEMBL
UniProt Splice Variant
Entrez Gene 30954
UniGene Mm.407012
RefSeq NM_001161737 NM_013929
OMIM
CCDS CCDS49189 CCDS26193
HPRD
IMGT
MGI ID MGI:1353606
MGI Symbol Siva1
EMBL AF033112 AF033113 AF033114 AF033115 AK010562 AK017570 AK153115 BC012279
GenPept AAC04706 AAD50058 AAD50059 AAD50060 AAH12279 BAB27029 BAB30811 BAE31732
RNA Seq Atlas 30954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca