InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Edem1

Summary

InnateDB Protein

IDBP-174711.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edem1

Protein Name

ER degradation enhancer, mannosidase alpha-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086565

InnateDB Gene

IDBG-174709 (Edem1)

Protein Structure

UniProt Annotation

Function

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity. {ECO:0000269PubMed:11375934}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0051787	misfolded protein binding