Mus musculus Protein: Epha5
Summary
InnateDB Protein IDBP-174720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epha5
Protein Name Eph receptor A5
Synonyms AI854630; AW125296; bsk; Cek7; Ehk1; Els1; Hek7; Rek7;
Species Mus musculus
Ensembl Protein ENSMUSP00000060646
InnateDB Gene IDBG-174718 (Epha5)
Protein Structure
UniProt Annotation
Function Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion. {ECO:0000269PubMed:12124402, ECO:0000269PubMed:17448994}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Disease Associations
Tissue Specificity Specifically expressed in the brain. Highly expressed in hippocampus, tenia tecta, indusium griseum and piriform cortex. The highest level of expression is found in the CA3 region of the hippocampus and the pyramidal cell layer of the piriform cortex. In addition, elevated levels of expression are also found in amygdala, medial septum, nucleus of the diagonal band, and in olfactory bulb. Expressed in pancreatic islet cells (at protein level). {ECO:0000269PubMed:17448994, ECO:0000269PubMed:8145300}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007411 axon guidance
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019933 cAMP-mediated signaling
GO:0021766 hippocampus development
GO:0032314 regulation of Rac GTPase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0048013 ephrin receptor signaling pathway
GO:0051964 negative regulation of synapse assembly
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:99654
InterPro IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00069
PF01404
PF07714
PF00041
PF01108
PF07647
PF00536
PRINTS PR00109
PIRSF
SMART SM00615
SM00454
SM00220
SM00060
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60629
PhosphoSite PhosphoSite-Q60629
TrEMBL
UniProt Splice Variant
Entrez Gene 13839
UniGene Mm.137991
RefSeq NP_031963
MGI ID
MGI Symbol Epha5
OMIM
CCDS CCDS19376
HPRD
IMGT
EMBL AC101956 AC114638 AC129220 AC132597 U07357
GenPept AAA17038