Mus musculus Protein: Clu
InnateDB Protein IDBP-174738.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clu
Protein Name clusterin
Synonyms AI893575; ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40; Sugp-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000022616
InnateDB Gene IDBG-174736 (Clu)
Protein Structure
UniProt Annotation
Function Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:12551933}. Nucleus {ECO:0000269PubMed:12551933}. Cytoplasm {ECO:0000269PubMed:12551933}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269PubMed:12551933}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Most abundant in stomach, liver, brain, and testis, with intermediate levels in heart, ovary and kidney.
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0051787 misfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001774 microglial cell activation
GO:0008219 cell death
GO:0009615 response to virus
GO:0017038 protein import
GO:0032286 central nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463 negative regulation of protein homooligomerization
GO:0032760 positive regulation of tumor necrosis factor production
GO:0043065 positive regulation of apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050821 protein stabilization
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051131 chaperone-mediated protein complex assembly
GO:0051788 response to misfolded protein
GO:0061077 chaperone-mediated protein folding
GO:0061518 microglial cell proliferation
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900221 regulation of beta-amyloid clearance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of beta-amyloid formation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 negative regulation of beta-amyloid formation
GO:1902847 regulation of neuronal signal transduction
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0031966 mitochondrial membrane
GO:0034366 spherical high-density lipoprotein particle
GO:0042583 chromaffin granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
GO:0097418 neurofibrillary tangle
GO:0097440 apical dendrite
Protein Structure and Domains
PDB ID MGI:88423
InterPro IPR000753 Clusterin-like
IPR016014 Clusterin, N-terminal
IPR016015 Clusterin, C-terminal
IPR016016 Clusterin
PFAM PF01093
Post-translational Modifications
SwissProt Q06890
PhosphoSite PhosphoSite-Q06890
UniProt Splice Variant
Entrez Gene 12759
RefSeq NP_038520
MGI Symbol Clu
EMBL AC126444 AF182509 AF248057 AK132030 BC075668 D14077 L05670 L08235 S70244
GenPept AAA37284 AAA37422 AAB30623 AAF06365 AAF67184 AAH75668 BAA03162 BAE20954