Mus musculus Gene: Clu
Summary
InnateDB Gene IDBG-174736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clu
Gene Name clusterin
Synonyms AI893575; ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40; Sugp-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000022037
Encoded Proteins
clusterin
clusterin
clusterin
clusterin
clusterin
clusterin
clusterin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:65968483-65981548
Strand Forward strand
Band D1
Transcripts
ENSMUST00000022616 ENSMUSP00000022616
ENSMUST00000138665 ENSMUSP00000121056
ENSMUST00000146990
ENSMUST00000153460 ENSMUSP00000121633
ENSMUST00000127387 ENSMUSP00000114720
ENSMUST00000138191 ENSMUSP00000117555
ENSMUST00000128539 ENSMUSP00000121485
ENSMUST00000144619 ENSMUSP00000117953
ENSMUST00000152903
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0051787 misfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001774 microglial cell activation
GO:0008219 cell death
GO:0009615 response to virus
GO:0017038 protein import
GO:0032286 central nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463 negative regulation of protein homooligomerization
GO:0032760 positive regulation of tumor necrosis factor production
GO:0043065 positive regulation of apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050821 protein stabilization
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051131 chaperone-mediated protein complex assembly
GO:0051788 response to misfolded protein
GO:0061077 chaperone-mediated protein folding
GO:0061518 microglial cell proliferation
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900221 regulation of beta-amyloid clearance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of beta-amyloid formation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 negative regulation of beta-amyloid formation
GO:1902847 regulation of neuronal signal transduction
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0031966 mitochondrial membrane
GO:0034366 spherical high-density lipoprotein particle
GO:0042583 chromaffin granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
GO:0097418 neurofibrillary tangle
GO:0097440 apical dendrite
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_013492 XM_006518503 XM_006518504
OMIM
CCDS CCDS36957
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas