Mus musculus Protein: Trip12 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-174832.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Trip12 | ||||||||||||||||||||||
Protein Name | thyroid hormone receptor interactor 12 | ||||||||||||||||||||||
Synonyms | 1110036I07Rik; 6720416K24Rik; AA410158; Gtl6; TRIP-12; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000027421 | ||||||||||||||||||||||
InnateDB Gene | IDBG-174830 (Trip12) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus, nucleoplasm {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1309481 | ||||||||||||||||||||||
InterPro |
IPR000569
HECT IPR004170 WWE domain IPR016024 Armadillo-type fold IPR018123 WWE domain, subgroup |
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PFAM |
PF00632
PF02825 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00119
SM00678 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | G5E870 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-NP_598736 | ||||||||||||||||||||||
TrEMBL | Q3TP48 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 14897 | ||||||||||||||||||||||
UniGene | Mm.470326 | ||||||||||||||||||||||
RefSeq | NP_598736 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Trip12 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS35633 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC123882 AK034814 AK134397 AK158807 AK164719 BC034113 CH466629 | ||||||||||||||||||||||
GenPept | AAH34113 BAC28839 BAE22126 BAE34675 BAE37889 EDL02171 EDL02178 EDL02182 | ||||||||||||||||||||||