InnateDB Protein
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IDBP-175367.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C80913
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Protein Name
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expressed sequence C80913
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Synonyms
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C80913; NNX3; Rmp;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000082646
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InnateDB Gene
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IDBG-175365 (C80913)
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Protein Structure
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Function |
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region (By similarity). {ECO:0000250}.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9878255}. Cytoplasm {ECO:0000269PubMed:9878255}. Mitochondrion {ECO:0000269PubMed:9878255}. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 in mitochondrion.
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Disease Associations |
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Tissue Specificity |
Expressed in the spinal cord, ganglia, choroid plexus and olfactors epithelium of the developing brain. Expressed in skin, lung, kidney, testis and muscles (at protein level). Expressed strongly in brain and kidney. Expressed weakly in skeletal muscle, lung and liver. {ECO:0000269PubMed:9878255}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001558
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regulation of cell growth
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GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006457
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protein folding
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GO:0009615
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response to virus
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GO:0010923
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negative regulation of phosphatase activity
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GO:0071363
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cellular response to growth factor stimulus
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GO:0071383
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cellular response to steroid hormone stimulus
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GO:2001243
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negative regulation of intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:1342294
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InterPro |
IPR004127
Prefoldin alpha-like
IPR009053
Prefoldin
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PFAM |
PF02996
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3TLD5
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PhosphoSite |
PhosphoSite-Q3TLD5
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TrEMBL |
Q3TNS3
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UniProt Splice Variant |
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Entrez Gene |
19777
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UniGene |
Mm.452855
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RefSeq |
NP_035404
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MGI ID |
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MGI Symbol |
Uri1
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OMIM |
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CCDS |
CCDS21157
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HPRD |
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IMGT |
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EMBL |
AF091096
AK133383
AK165045
AK166566
BC023029
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GenPept |
AAD08680
AAH23029
BAE21626
BAE38015
BAE38857
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