Version 5.4
Mus musculus Gene: C80913
Summary
InnateDB Gene IDBG-175365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C80913
Gene Name expressed sequence C80913
Synonyms C80913; NNX3; Rmp
Species Mus musculus
Ensembl Gene ENSMUSG00000030421
Encoded Proteins
IDBP-175367
expressed sequence C80913
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105176:
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:37960002-38019542
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000085513 ENSMUSP00000082646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001558 regulation of cell growth
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006457 protein folding
GO:0009615 response to virus
GO:0010923 negative regulation of phosphatase activity
GO:0071363 cellular response to growth factor stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016272 prefoldin complex
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105176
View Gene Order
ENSBTAG00000007559
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.387220 Mm.392674 Mm.452855
RefSeq NM_011274 XM_006539676 XM_006539677 XM_006539678
OMIM
CCDS CCDS21157
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca