InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Enc1

Summary

InnateDB Protein

IDBP-175384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Enc1

Protein Name

ectodermal-neural cortex 1

Synonyms

Nrpb; PIG10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038783

InnateDB Gene

IDBG-175382 (Enc1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus matrix {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton. Note=Interacts with the actin cytoskeleton.

Disease Associations

Tissue Specificity

Primarily expressed in the nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0010976	positive regulation of neuron projection development
GO:0016567	protein ubiquitination
GO:0017148	negative regulation of translation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016363	nuclear matrix
GO:0031463	Cul3-RING ubiquitin ligase complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:109610

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt