Version 5.4
Mus musculus Gene: Enc1
Summary
InnateDB Gene IDBG-175382.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Enc1
Gene Name ectodermal-neural cortex 1
Synonyms Nrpb; PIG10
Species Mus musculus
Ensembl Gene ENSMUSG00000041773
Encoded Proteins
IDBP-175384
ectodermal-neural cortex 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171617:
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:97241105-97253039
Strand Forward strand
Band D1
Transcripts
ENSMUST00000041623 ENSMUSP00000038783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010976 positive regulation of neuron projection development
GO:0016567 protein ubiquitination
GO:0017148 negative regulation of translation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016363 nuclear matrix
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171617
View Gene Order
ENSBTAG00000026369
Not yet available
Cross-References
SwissProt O35709
TrEMBL
UniProt Splice Variant
Entrez Gene 13803
UniGene Mm.241073 Mm.472435
RefSeq NM_007930
OMIM
CCDS CCDS26710
HPRD
IMGT
MGI ID MGI:109610
MGI Symbol Enc1
EMBL AK049187 AK132173 BC049186 BC058098 CH466567 U65079
GenPept AAB64206 AAH49186 AAH58098 BAC33597 BAE21011 EDL00871
RNA Seq Atlas 13803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca