Version 5.4
Mus musculus Protein: Nudt14
Summary
InnateDB Protein IDBP-175410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nudt14
Protein Name nudix (nucleoside diphosphate linked moiety X)-type motif 14
Synonyms 1110030M18Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000002881
InnateDB Gene IDBG-175408 (Nudt14)
Protein Structure
UniProt Annotation
Function Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008768 UDP-sugar diphosphatase activity
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1913424
InterPro IPR000086 NUDIX hydrolase domain
IPR004385 Nucleoside diphosphate pyrophosphatase
IPR015797 NUDIX hydrolase domain-like
PFAM PF00293
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D142
PhosphoSite PhosphoSite-Q9D142
TrEMBL
UniProt Splice Variant
Entrez Gene 66174
UniGene
RefSeq NP_079675
MGI ID
MGI Symbol Nudt14
OMIM
CCDS CCDS26201
HPRD
IMGT
EMBL AK003991 AK013174 BC025444
GenPept AAH25444 BAB23110 BAB28691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca