InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WHSC1L1

Summary

InnateDB Protein

IDBP-17580.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WHSC1L1

Protein Name

Wolf-Hirschhorn syndrome candidate 1-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313410

InnateDB Gene

IDBG-17572 (WHSC1L1)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269PubMed:16682010}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.

Disease Associations

Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

Tissue Specificity

Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. {ECO:0000269PubMed:11374904}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016571	histone methylation
GO:0034968	histone lysine methylation