InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrp2

Summary

InnateDB Protein

IDBP-176229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrp2

Protein Name

low density lipoprotein receptor-related protein 2

Synonyms

AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; Gp330; Megalin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079752

InnateDB Gene

IDBG-176227 (Lrp2)

Protein Structure

UniProt Annotation

Function

Acts together with cubilin to mediate HDL endocytosis. {ECO:0000269PubMed:10766831}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Membrane, coated pit {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0008283	cell proliferation
GO:0030900	forebrain development

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005903	brush border
GO:0005905	coated pit
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0031526	brush border membrane
GO:0043235	receptor complex
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95794

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF00058
PF00008
PF07645
PF00057

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00179
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt