InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrp2

Summary

InnateDB Gene

IDBG-176227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrp2

Gene Name

low density lipoprotein receptor-related protein 2

Synonyms

AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; Gp330; Megalin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027070

Encoded Proteins

IDBP-176229

low density lipoprotein receptor-related protein 2

IDBP-176233

low density lipoprotein receptor-related protein 2

IDBP-176235

low density lipoprotein receptor-related protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081479:
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:69424340-69586065

Strand

Reverse strand

Band

Transcripts

ENSMUST00000080953	ENSMUSP00000079752
ENSMUST00000100051	ENSMUSP00000097628
ENSMUST00000092551	ENSMUSP00000090212
ENSMUST00000128742

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0008283	cell proliferation
GO:0030900	forebrain development

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005903	brush border
GO:0005905	coated pit
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0031526	brush border membrane
GO:0043235	receptor complex
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome