InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thop1

Summary

InnateDB Protein

IDBP-176846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thop1

Protein Name

thimet oligopeptidase 1

Synonyms

AI131655; AI327041; EP24.15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005057

InnateDB Gene

IDBG-176844 (Thop1)

Protein Structure

UniProt Annotation

Function

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042277	peptide binding
GO:0046872	metal ion binding