InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkab2

Summary

InnateDB Protein

IDBP-177137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkab2

Protein Name

protein kinase, AMP-activated, beta 2 non-catalytic subunit

Synonyms

5730553K21Rik; AW049591; BB124140;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036410

InnateDB Gene

IDBG-177135 (Prkab2)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.