Version 5.4
| Mus musculus Gene: Prkab2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-177135.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Prkab2 | ||||||||||||||||||||||
| Gene Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit | ||||||||||||||||||||||
| Synonyms | 5730553K21Rik; AW049591; BB124140 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000038205 | ||||||||||||||||||||||
| Encoded Proteins |
protein kinase, AMP-activated, beta 2 non-catalytic subunit
protein kinase, AMP-activated, beta 2 non-catalytic subunit
protein kinase, AMP-activated, beta 2 non-catalytic subunit
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131791:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 3:97658193-97673812 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | F2.2 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Organelle biogenesis and maintenance pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Regulation of AMPK activity via LKB1 pathway
Signaling by Insulin receptor pathway
Integration of energy metabolism pathway
Membrane Trafficking pathway
Metabolism pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Metabolism of lipids and lipoproteins pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Regulation of Rheb GTPase activity by AMPK pathway
PI3K Cascade pathway
AMPK inhibits chREBP transcriptional activation activity pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signal Transduction pathway
Mitochondrial biogenesis pathway
mTOR signalling pathway
PKB-mediated events pathway
Translocation of GLUT4 to the plasma membrane pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
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| KEGG |
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Circadian rhythm pathway
Hypertrophic cardiomyopathy (HCM) pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
Leptin pathway
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| REACTOME |
Regulation of Rheb GTPase activity by AMPK pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
AMPK inhibits chREBP transcriptional activation activity pathway
Integration of energy metabolism pathway
Translocation of GLUT4 to the plasma membrane pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Organelle biogenesis and maintenance pathway
Metabolism of lipids and lipoproteins pathway
PKB-mediated events pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Mitochondrial biogenesis pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Metabolism pathway
Membrane Trafficking pathway
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| KEGG |
Circadian rhythm pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Hypertrophic cardiomyopathy (HCM) pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.31175 | ||||||||||||||||||||||
| RefSeq | NM_182997 XM_006500840 XM_006500841 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS17657 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||