Version 5.4
Mus musculus Protein: Gpt2
Summary
InnateDB Protein IDBP-177269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpt2
Protein Name glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms 4631422C05Rik; ALT2; AU014768; AU041193; C87201;
Species Mus musculus
Ensembl Protein ENSMUSP00000034136
InnateDB Gene IDBG-177267 (Gpt2)
Protein Structure
UniProt Annotation
Function Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Specifically induced in fatty liver. Highly expressed in muscle, liver and white adipose tissue. Moderately expressed in brain and kidney and expressed at low levels in the heart. {ECO:0000269PubMed:15122758}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0009058 biosynthetic process
GO:0042851 L-alanine metabolic process
GO:0042853 L-alanine catabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1915391
InterPro IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00155
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGT5
PhosphoSite PhosphoSite-Q8BGT5
TrEMBL
UniProt Splice Variant
Entrez Gene 108682
UniGene Mm.200423
RefSeq NP_776291
MGI ID
MGI Symbol Gpt2
OMIM
CCDS CCDS22499
HPRD
IMGT
EMBL AK033424 AK075894 AK076250 AK082030 BC034219 BK005128
GenPept AAH34219 BAC28282 BAC36035 BAC36274 BAC38395 DAA05290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca