InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ltb

Summary

InnateDB Protein

IDBP-177331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ltb

Protein Name

lymphotoxin B

Synonyms

AI662801; LTbeta; p33; Tnfc; Tnfsf3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025262

InnateDB Gene

IDBG-177329 (Ltb)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0010467	gene expression
GO:0043588	skin development
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0048535	lymph node development