Mus musculus Gene: Ltb
Summary
InnateDB Gene IDBG-177329.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltb
Gene Name lymphotoxin B
Synonyms AI662801; LTbeta; p33; Tnfc; Tnfsf3;
Species Mus musculus
Ensembl Gene ENSMUSG00000024399
Encoded Proteins
lymphotoxin B
lymphotoxin B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000227507:
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35194439-35196320
Strand Forward strand
Band B1
Transcripts
ENSMUST00000025262 ENSMUSP00000025262
ENSMUST00000173510
ENSMUST00000173600 ENSMUSP00000134706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0010467 gene expression
GO:0043588 skin development
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0048535 lymph node development
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G3V002
UniProt Splice Variant
Entrez Gene 16994
UniGene Mm.1715
RefSeq NM_008518
OMIM
CCDS CCDS28690
HPRD
IMGT
MGI ID MGI:104796
MGI Symbol Ltb
EMBL CR974444
GenPept
RNA Seq Atlas 16994