InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Twf1

Summary

InnateDB Protein

IDBP-177410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Twf1

Protein Name

twinfilin, actin-binding protein, homolog 1 (Drosophila)

Synonyms

A6; Ptk9; twinfilin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023087

InnateDB Gene

IDBG-177408 (Twf1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. {ECO:0000269PubMed:10669753, ECO:0000269PubMed:15282541, ECO:0000269PubMed:16511569, ECO:0000269PubMed:9249064}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10669753}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10669753}. Note=Diffuse cytoplasmic localization with perinuclear and G- actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain, liver and kidney. Also expressed in heart, lung and testis. Not detected in spleen or skeletal muscle. {ECO:0000269PubMed:10669753, ECO:0000269PubMed:12807912, ECO:0000269PubMed:9249064}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030837	negative regulation of actin filament polymerization
GO:0042989	sequestering of actin monomers
GO:0043538	regulation of actin phosphorylation
GO:0051016	barbed-end actin filament capping

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0030016	myofibril
GO:0030175	filopodium
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm