InnateDB Protein
|
IDBP-177595.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Kcne1
|
Protein Name
|
potassium voltage-gated channel, Isk-related subfamily, member 1
|
Synonyms
|
Isk; MinK; nmf190;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000052248
|
InnateDB Gene
|
IDBG-177593 (Kcne1)
|
Protein Structure
|
|
Function |
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Membrane; Single-pass type I membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Restrictively localized in the apical membrane portion of epithelial cells.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005249
|
voltage-gated potassium channel activity
|
GO:0005251
|
delayed rectifier potassium channel activity
|
GO:0005515
|
protein binding
|
GO:0015459
|
potassium channel regulator activity
|
GO:0031433
|
telethonin binding
|
GO:0046982
|
protein heterodimerization activity
|
GO:1902282
|
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
|
|
Biological Process |
GO:0002070
|
epithelial cell maturation
|
GO:0006487
|
protein N-linked glycosylation
|
GO:0006493
|
protein O-linked glycosylation
|
GO:0006811
|
ion transport
|
GO:0008584
|
male gonad development
|
GO:0060047
|
heart contraction
|
GO:0060307
|
regulation of ventricular cardiac muscle cell membrane repolarization
|
GO:0071320
|
cellular response to cAMP
|
GO:0071435
|
potassium ion export
|
GO:0071468
|
cellular response to acidity
|
GO:0086005
|
ventricular cardiac muscle cell action potential
|
GO:0086013
|
membrane repolarization during cardiac muscle cell action potential
|
GO:0086091
|
regulation of heart rate by cardiac conduction
|
GO:0090315
|
negative regulation of protein targeting to membrane
|
GO:1901381
|
positive regulation of potassium ion transmembrane transport
|
GO:1902259
|
regulation of delayed rectifier potassium channel activity
|
|
Cellular Component |
|
PDB ID |
MGI:96673
|
InterPro |
IPR000369
Potassium channel, voltage-dependent, beta subunit, KCNE
IPR005424
Potassium channel, voltage-dependent, beta subunit, KCNE1
|
PFAM |
PF02060
|
PRINTS |
PR00168
PR01604
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P23299
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q545H6
|
UniProt Splice Variant |
|
Entrez Gene |
16509
|
UniGene |
Mm.299425
|
RefSeq |
NP_032450
|
MGI ID |
|
MGI Symbol |
Kcne1
|
OMIM |
|
CCDS |
CCDS28336
|
HPRD |
|
IMGT |
|
EMBL |
AK008938
AK028907
BC094276
CH466602
X60457
|
GenPept |
AAH94276
BAB25979
BAC26189
CAA42990
EDL03786
EDL03787
|
|
|