InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcne1

Summary

InnateDB Gene

IDBG-177593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcne1

Gene Name

potassium voltage-gated channel, Isk-related subfamily, member 1

Synonyms

Isk; MinK; nmf190

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039639

Encoded Proteins

IDBP-177595

potassium voltage-gated channel, Isk-related subfamily, member 1

IDBP-625958

potassium voltage-gated channel, Isk-related subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180509:
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:92346001-92359468

Strand

Reverse strand

Band

Transcripts

ENSMUST00000051705	ENSMUSP00000052248
ENSMUST00000166707	ENSMUSP00000130866

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0031433	telethonin binding
GO:0046982	protein heterodimerization activity
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process

GO:0002070	epithelial cell maturation
GO:0006487	protein N-linked glycosylation
GO:0006493	protein O-linked glycosylation
GO:0006811	ion transport
GO:0008584	male gonad development
GO:0060047	heart contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071320	cellular response to cAMP
GO:0071435	potassium ion export
GO:0071468	cellular response to acidity
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090315	negative regulation of protein targeting to membrane
GO:1901381	positive regulation of potassium ion transmembrane transport
GO:1902259	regulation of delayed rectifier potassium channel activity

Cellular Component

GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0008076	voltage-gated potassium channel complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030018	Z disc

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000180509

View Gene Order

ENSBTAG00000001150

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.299425

RefSeq

NM_008424 XM_006522941

OMIM

CCDS

CCDS28336

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas