InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spg21

Summary

InnateDB Protein

IDBP-177907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spg21

Protein Name

spastic paraplegia 21 homolog (human)

Synonyms

ACP33; BM-019; C78576; D9Wsu18e; GL010; MAST;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034955

InnateDB Gene

IDBG-177905 (Spg21)

Protein Structure

UniProt Annotation

Function

May play a role as a negative regulatory factor in CD4- dependent T-cell activation. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in cell lines FT.1 and in a L cell fibroblast derivative (at protein level). {ECO:0000269PubMed:11113139}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042609	CD4 receptor binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030140	trans-Golgi network transport vesicle

Protein Structure and Domains

PDB ID

MGI:106403

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561

PRINTS

PR00111

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQC8

PhosphoSite

PhosphoSite-Q9CQC8

TrEMBL

A2RT57

UniProt Splice Variant

Entrez Gene

27965

UniGene

Mm.272475

RefSeq

NP_613050

MGI ID

MGI Symbol

Spg21

OMIM

CCDS

CCDS23293

HPRD

IMGT

EMBL

AK009332 AK011985 AK090017 AK149930 AK150215 AK150581 AK153284 AK170666 BC099434 BC132377 BC132403 CH466522

GenPept

AAH99434 AAI32378 AAI32404 BAB26224 BAB27958 BAC41047 BAE29174 BAE29385 BAE29675 BAE31867 BAE41947 EDL26096