InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cactin

Summary

InnateDB Protein

IDBP-178036.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cactin

Protein Name

RIKEN cDNA 2510012J08 gene

Synonyms

2510012J08Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059533

InnateDB Gene

IDBG-178034 (Cactin)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in cortex, hippocampus, cerebellum, heart, lung, kidney, liver, spleen and thymus. {ECO:0000269PubMed:20829348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006397	mRNA processing
GO:0007275	multicellular organismal development
GO:0008380	RNA splicing
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032688	negative regulation of interferon-beta production
GO:0032717	negative regulation of interleukin-8 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0045087	innate immune response
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor