Mus musculus Gene: Cactin
Summary
InnateDB Gene IDBG-178034.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cactin
Gene Name cactin, spliceosome C complex subunit
Synonyms 2510012J08Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000034889
Encoded Proteins
RIKEN cDNA 2510012J08 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] C19orf29 (Cactin) is a novel negative regulator of TLR signalling that targets the MHC class III protein I{kappa}B like (I{kappa}BL) and inhibits NFkappaB and IRF signalling pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105298:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81321103-81326251
Strand Forward strand
Band C1
Transcripts
ENSMUST00000050867 ENSMUSP00000059533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006397 mRNA processing
GO:0007275 multicellular organismal development
GO:0008380 RNA splicing
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032688 negative regulation of interferon-beta production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0045087 innate immune response
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9CS00
TrEMBL A1L013
UniProt Splice Variant
Entrez Gene 70312
UniGene Mm.479062 Mm.87628
RefSeq NM_027381
OMIM
CCDS CCDS35995
HPRD
IMGT
MGI ID MGI:1917562
MGI Symbol Cactin
EMBL AC155937 AK010963 AY934504 BC150986 BC151180
GenPept AAI50987 AAI51181 AAY17367 BAB27295
RNA Seq Atlas 70312