Version 5.4
Mus musculus Gene: Cactin
Summary
InnateDB Gene IDBG-178034.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cactin
Gene Name cactin, spliceosome C complex subunit
Synonyms 2510012J08Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000034889
Encoded Proteins
IDBP-178036
RIKEN cDNA 2510012J08 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20829348
[Homo sapiens] C19orf29 (Cactin) is a novel negative regulator of TLR signalling that targets the MHC class III protein I{kappa}B like (I{kappa}BL) and inhibits NFkappaB and IRF signalling pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105298:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81321103-81326251
Strand Forward strand
Band C1
Transcripts
ENSMUST00000050867 ENSMUSP00000059533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006397 mRNA processing
GO:0007275 multicellular organismal development
GO:0008380 RNA splicing
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032688 negative regulation of interferon-beta production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0045087 innate immune response
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105298
View Gene Order
ENSBTAG00000010373
Not yet available
Cross-References
SwissProt Q9CS00
TrEMBL A1L013
UniProt Splice Variant
Entrez Gene 70312
UniGene Mm.479062 Mm.87628
RefSeq NM_027381
OMIM
CCDS CCDS35995
HPRD
IMGT
MGI ID MGI:1917562
MGI Symbol Cactin
EMBL AC155937 AK010963 AY934504 BC150986 BC151180
GenPept AAI50987 AAI51181 AAY17367 BAB27295
RNA Seq Atlas 70312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca