Version 5.4
| Mus musculus Protein: Habp2 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-178184.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Habp2 | ||||||||||
| Protein Name | hyaluronic acid binding protein 2 | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000077402 | ||||||||||
| InnateDB Gene | IDBG-178182 (Habp2) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Liver and kidney. {ECO:0000269PubMed:9401717}. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:1196378 | ||||||||||
| InterPro |
IPR000001
Kringle IPR000742 Epidermal growth factor-like domain IPR001254 Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR001881 EGF-like calcium-binding domain IPR009003 Trypsin-like cysteine/serine peptidase domain IPR013806 Kringle-like fold |
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| PFAM |
PF00051
PF00008 PF00089 PF07645 |
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| PRINTS |
PR00722
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| PIRSF | |||||||||||
| SMART |
SM00130
SM00181 SM00020 SM00179 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q8K0D2 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | F7B276 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 226243 | ||||||||||
| UniGene | Mm.25791 | ||||||||||
| RefSeq | XP_006527077 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Habp2 | ||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AC115771 AC161579 BC031775 | ||||||||||
| GenPept | AAH31775 | ||||||||||