InnateDB Protein
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IDBP-178954.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hr
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Protein Name
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hairless
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Synonyms
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ALUNC; AU; ba; bldy; hr; N; rh; rh-bmh; rhino;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022691
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InnateDB Gene
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IDBG-178952 (Hr)
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Protein Structure
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Function |
Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Note=Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.
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Tissue Specificity |
Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96223
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InterPro |
IPR003347
JmjC domain
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PFAM |
PF02373
PF08007
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PRINTS |
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PIRSF |
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SMART |
SM00558
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TIGRFAMs |
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Modification |
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SwissProt |
Q61645
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PhosphoSite |
PhosphoSite-Q61645
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
15460
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UniGene |
Mm.7598
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RefSeq |
NP_068677
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MGI ID |
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MGI Symbol |
Hr
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OMIM |
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CCDS |
CCDS27257
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HPRD |
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IMGT |
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EMBL |
BC049182
Z32675
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GenPept |
AAH49182
CAA83587
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