Version 5.4
Mus musculus Gene: Hr
Summary
InnateDB Gene IDBG-178952.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hr
Gene Name hairless
Synonyms ALUNC; AU; ba; bldy; hr; N; rh; rh-bmh; rhino
Species Mus musculus
Ensembl Gene ENSMUSG00000022096
Encoded Proteins
IDBP-178954
hairless
IDBP-534570
hairless
IDBP-536552
hairless
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory ORF that exists upstream of the primary ORF. Mutations in this upstream ORF, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70552212-70573548
Strand Forward strand
Band D2
Transcripts
ENSMUST00000022691 ENSMUSP00000022691
ENSMUST00000159959
ENSMUST00000161468
ENSMUST00000161069 ENSMUSP00000124816
ENSMUST00000163060 ENSMUSP00000124042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016604 nuclear body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168453
View Gene Order
ENSBTAG00000012036
Not yet available
Cross-References
SwissProt
TrEMBL E9PZ81
UniProt Splice Variant
Entrez Gene 15460
UniGene Mm.7598
RefSeq NM_021877
OMIM
CCDS CCDS27257
HPRD
IMGT
MGI ID MGI:96223
MGI Symbol Hr
EMBL AC122268 BC049182 Z32675
GenPept AAH49182 CAA83587
RNA Seq Atlas 15460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca