InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdac7

Summary

InnateDB Protein

IDBP-179046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac7

Protein Name

histone deacetylase 7

Synonyms

5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078766

InnateDB Gene

IDBG-179042 (Hdac7)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. {ECO:0000269PubMed:10640276}.

Subcellular Localization

Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

Disease Associations

Tissue Specificity

Highly expressed in heart and lung. Expressed at intermediate level in muscle. {ECO:0000269PubMed:10640276, ECO:0000269PubMed:11279209}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	109 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033613	activating transcription factor binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491	repressing transcription factor binding
GO:0071889	14-3-3 protein binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007043	cell-cell junction assembly
GO:0007399	nervous system development
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0030183	B cell differentiation
GO:0032703	negative regulation of interleukin-2 production
GO:0042113	B cell activation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045843	negative regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis