Version 5.4
Mus musculus Gene: Hdac7
Summary
InnateDB Gene IDBG-179042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdac7
Gene Name histone deacetylase 7
Synonyms 5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062
Species Mus musculus
Ensembl Gene ENSMUSG00000022475
Encoded Proteins
IDBP-179044
histone deacetylase 7
IDBP-179046
histone deacetylase 7
IDBP-274197
histone deacetylase 7
IDBP-274199
histone deacetylase 7
IDBP-400962
histone deacetylase 7
IDBP-400961
histone deacetylase 7
IDBP-400957
histone deacetylase 7
IDBP-400958
histone deacetylase 7
IDBP-539636
histone deacetylase 7
IDBP-539360
histone deacetylase 7
IDBP-531571
histone deacetylase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061273:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:97792664-97844502
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000088402 ENSMUSP00000085744
ENSMUST00000079838 ENSMUSP00000078766
ENSMUST00000116409 ENSMUSP00000112110
ENSMUST00000116408 ENSMUSP00000112109
ENSMUST00000119670 ENSMUSP00000112459
ENSMUST00000121514 ENSMUSP00000112641
ENSMUST00000120683 ENSMUSP00000112446
ENSMUST00000118294 ENSMUSP00000113380
ENSMUST00000151334
ENSMUST00000156045 ENSMUSP00000120576
ENSMUST00000135651 ENSMUSP00000119970
ENSMUST00000134258 ENSMUSP00000118599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 109 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033613 activating transcription factor binding
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491 repressing transcription factor binding
GO:0071889 14-3-3 protein binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0006351 transcription, DNA-templated
GO:0006954 inflammatory response
GO:0007043 cell-cell junction assembly
GO:0007399 nervous system development
GO:0008152 metabolic process
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0030183 B cell differentiation
GO:0032703 negative regulation of interleukin-2 production
GO:0042113 B cell activation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000061273
View Gene Order
ENSBTAG00000026819
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
hdac_classii_pathway
Signaling events mediated by HDAC Class II
hif1_tfpathway
HIF-1-alpha transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001204275 NM_001204276 NM_001204277 NM_001204278 NM_001204279 NM_001204280 NM_001204281 NM_019572 XM_006521197 XM_006521198 XM_006521199 XM_006521201 XM_006521202 XM_006521203 XM_006521204 XM_006521205 XM_006521206 XM_006521207 XM_006521208 XM_006521209 XM_006521210
OMIM
CCDS CCDS37188 CCDS57001 CCDS57002 CCDS57003 CCDS57004 CCDS57005 CCDS57006 CCDS57007
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca