InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd180

Summary

InnateDB Protein

IDBP-179055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd180

Protein Name

CD180 antigen

Synonyms

F630107B15; Ly78; RP105;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022124

InnateDB Gene

IDBG-179053 (Cd180)

Protein Structure

UniProt Annotation

Function

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. {ECO:0000269PubMed:10880523}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002322	B cell proliferation involved in immune response
GO:0006954	inflammatory response
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045087	innate immune response
GO:0071222	cellular response to lipopolysaccharide