Version 5.4
Mus musculus Protein: Spib
Summary
InnateDB Protein IDBP-179082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spib
Protein Name Spi-B transcription factor (Spi-1/PU.1 related)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096084
InnateDB Gene IDBG-179078 (Spib)
Protein Structure
UniProt Annotation
Function Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269PubMed:10229183, ECO:0000269PubMed:11313289, ECO:0000269PubMed:11672537, ECO:0000269PubMed:11980719, ECO:0000269PubMed:12431391, ECO:0000269PubMed:8691135, ECO:0000269PubMed:9384589}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in the medulla of the thymus, the spleen and germinal centers of the lymph nodes. Expressed in B- cells and T-cells, expression increases during B-cell maturation and decreases during T-cell maturation. {ECO:0000269PubMed:8691135}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030225 macrophage differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:892986
InterPro IPR000418 Ets domain
PFAM PF00178
PRINTS PR00454
PIRSF
SMART SM00413
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35906
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 272382
UniGene Mm.8012
RefSeq XP_006540995
MGI ID
MGI Symbol Spib
OMIM
CCDS
HPRD
IMGT
EMBL U87614 U87616 U87617 U87618 U87619 U87620
GenPept AAC53554 AAC53556 AAC53557 AAC53559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca