Version 5.4
Mus musculus Gene: Spib
Summary
InnateDB Gene IDBG-179078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spib
Gene Name Spi-B transcription factor (Spi-1/PU.1 related)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000008193
Encoded Proteins
IDBP-179080
Spi-B transcription factor (Spi-1/PU.1 related)
IDBP-179082
Spi-B transcription factor (Spi-1/PU.1 related)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142539:
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44525995-44532071
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000035323 ENSMUSP00000035539
ENSMUST00000098483 ENSMUSP00000096084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030225 macrophage differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142539
View Gene Order
ENSBTAG00000043953
Not yet available
Cross-References
SwissProt O35906
TrEMBL
UniProt Splice Variant
Entrez Gene 272382
UniGene Mm.8012
RefSeq NM_019866 XM_006540932 XM_006540933 XM_006540935 XM_006540936 XM_006540937 XM_006540938 XM_006540939 XM_006540940 XM_006540941
OMIM
CCDS CCDS21209
HPRD
IMGT
MGI ID MGI:892986
MGI Symbol Spib
EMBL U87614 U87616 U87617 U87618 U87619 U87620
GenPept AAC53554 AAC53556 AAC53557 AAC53559
RNA Seq Atlas 272382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca