Version 5.4
Mus musculus Protein: Cyld
Summary
InnateDB Protein IDBP-179178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyld
Protein Name cylindromatosis (turban tumor syndrome)
Synonyms 2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; CYLD1; EAC; mKIAA0849;
Species Mus musculus
Ensembl Protein ENSMUSP00000039834
InnateDB Gene IDBG-179176 (Cyld)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070064 proline-rich region binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007346 regulation of mitotic cell cycle
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0045087 innate immune response (InnateDB)
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070536 protein K63-linked deubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0030496 midbody
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Protein Structure and Domains
PDB ID MGI:1921506
InterPro IPR000938 CAP Gly-rich domain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF01302
PF00443
PRINTS
PIRSF
SMART SM01052
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Z4YJJ5
UniProt Splice Variant
Entrez Gene 74256
UniGene Mm.490395
RefSeq
MGI ID
MGI Symbol Cyld
OMIM
CCDS
HPRD
IMGT
EMBL AC138025 AC156937 AK134926
GenPept BAE22340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca