InnateDB Protein
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IDBP-179424.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Xpo7
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Protein Name
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exportin 7
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Synonyms
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4930506C02Rik; BB164534; mKIAA0745; Ranbp16;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022696
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InnateDB Gene
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IDBG-179422 (Xpo7)
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Protein Structure
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Function |
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis and spleen, moderate in kidney and liver and low in heart, brain, lung and skeletal muscle. {ECO:0000269PubMed:11071879}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929705
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InterPro |
IPR001494
Importin-beta, N-terminal domain
IPR016024
Armadillo-type fold
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PFAM |
PF03810
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PRINTS |
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PIRSF |
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SMART |
SM00913
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EPK7
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PhosphoSite |
PhosphoSite-Q9EPK7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
65246
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UniGene |
Mm.436084
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RefSeq |
NP_075532
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MGI ID |
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MGI Symbol |
Xpo7
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OMIM |
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CCDS |
CCDS36974
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HPRD |
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IMGT |
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EMBL |
AJ297360
AK028303
AK032768
AK035775
AK036837
AK041768
AK122361
AK164595
BC029702
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GenPept |
AAH29702
BAC25870
BAC28013
BAC29182
BAC29600
BAC31059
BAC65643
BAE37843
CAC17621
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