InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp1a1

Summary

InnateDB Protein

IDBP-179814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1a1

Protein Name

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms

Atpa-1; BC010319;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039657

InnateDB Gene

IDBG-179812 (Atp1a1)

Protein Structure

UniProt Annotation

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016791	phosphatase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030506	ankyrin binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0043531	ADP binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002028	regulation of sodium ion transport
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0008217	regulation of blood pressure
GO:0010107	potassium ion import
GO:0015672	monovalent inorganic cation transport
GO:0016311	dephosphorylation
GO:0031947	negative regulation of glucocorticoid biosynthetic process
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug
GO:0045822	negative regulation of heart contraction
GO:0045823	positive regulation of heart contraction
GO:0045989	positive regulation of striated muscle contraction
GO:0060081	membrane hyperpolarization
GO:0071260	cellular response to mechanical stimulus
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88105

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt