Mus musculus Gene: Atp1a1
Summary
InnateDB Gene IDBG-179812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp1a1
Gene Name ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms Atpa-1; BC010319;
Species Mus musculus
Ensembl Gene ENSMUSG00000033161
Encoded Proteins
ATPase, Na+/K+ transporting, alpha 1 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163399:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:101576219-101604603
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000036493 ENSMUSP00000039657
ENSMUST00000130649
ENSMUST00000136340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0016791 phosphatase activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829 cation-transporting ATPase activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030506 ankyrin binding
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0043531 ADP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046872 metal ion binding
GO:0051087 chaperone binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002028 regulation of sodium ion transport
GO:0006754 ATP biosynthetic process
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0008217 regulation of blood pressure
GO:0010107 potassium ion import
GO:0015672 monovalent inorganic cation transport
GO:0016311 dephosphorylation
GO:0031947 negative regulation of glucocorticoid biosynthetic process
GO:0035725 sodium ion transmembrane transport
GO:0042493 response to drug
GO:0045822 negative regulation of heart contraction
GO:0045823 positive regulation of heart contraction
GO:0045989 positive regulation of striated muscle contraction
GO:0060081 membrane hyperpolarization
GO:0071260 cellular response to mechanical stimulus
GO:0086004 regulation of cardiac muscle cell contraction
Cellular Component
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030315 T-tubule
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ion channel transport pathway
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Carbohydrate digestion and absorption pathway
Protein digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
TCR pathway
TSH pathway
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Carbohydrate digestion and absorption pathway
Protein digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8VDN2
TrEMBL Q3UF49 Q8K2R2
UniProt Splice Variant
Entrez Gene 11928
UniGene Mm.280103
RefSeq NM_144900
OMIM
CCDS CCDS17683
HPRD
IMGT
MGI ID MGI:88105
MGI Symbol Atp1a1
EMBL AK148989 BC010319 BC021496 BC023794 BC025618 BC025627 BC025811 BC030326 BC032187 BC033435 BC033471 BC042435
GenPept AAH10319 AAH21496 AAH23794 AAH25618 AAH25627 AAH25811 AAH30326 AAH32187 AAH33435 AAH33471 AAH42435 BAE28712
RNA Seq Atlas 11928