InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irx5

Summary

InnateDB Protein

IDBP-180172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irx5

Protein Name

Iroquois related homeobox 5 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034184

InnateDB Gene

IDBG-180170 (Irx5)

Protein Structure

UniProt Annotation

Function

Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Involved in craniofacial and gonadal development (By similarity). Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Not expressed in the developing metanephric kidney or adult kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002027	regulation of heart rate
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007601	visual perception
GO:0008406	gonad development
GO:0010468	regulation of gene expression
GO:0042551	neuron maturation
GO:0048468	cell development
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0050896	response to stimulus
GO:0060040	retinal bipolar neuron differentiation