InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v0b

Summary

InnateDB Protein

IDBP-180181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0b

Protein Name

ATPase, H+ transporting, lysosomal V0 subunit B

Synonyms

2310024H13Rik; Atp6f; VMA16;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047682

InnateDB Gene

IDBG-180179 (Atp6v0b)

Protein Structure

UniProt Annotation

Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Vacuole membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11441017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0005768	endosome
GO:0016021	integral component of membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain