InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v0b

Summary

InnateDB Gene

IDBG-180179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0b

Gene Name

ATPase, H+ transporting, lysosomal V0 subunit B

Synonyms

2310024H13Rik; Atp6f; VMA16

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033379

Encoded Proteins

IDBP-180181

ATPase, H+ transporting, lysosomal V0 subunit B

IDBP-543039

ATPase, H+ transporting, lysosomal V0 subunit B

IDBP-718379

IDBP-717703

IDBP-543040

ATPase, H+ transporting, lysosomal V0 subunit B

IDBP-718802

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117410:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:117884326-117887333

Strand

Reverse strand

Band

D2.1

Transcripts

ENSMUST00000036380	ENSMUSP00000047682
ENSMUST00000133530
ENSMUST00000150204	ENSMUSP00000119988
ENSMUST00000152356
ENSMUST00000124974
ENSMUST00000149868	ENSMUSP00000137788
ENSMUST00000132073	ENSMUSP00000137654
ENSMUST00000136596	ENSMUSP00000118538
ENSMUST00000147845	ENSMUSP00000137945

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0005768	endosome
GO:0016021	integral component of membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain