Version 5.4
Mus musculus Protein: Hoxd10
Summary
InnateDB Protein IDBP-181045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxd10
Protein Name homeobox D10
Synonyms AI385591; AI874987; Hox-4.5; Hox-5.3;
Species Mus musculus
Ensembl Protein ENSMUSP00000062412
InnateDB Gene IDBG-181043 (Hoxd10)
Protein Structure
UniProt Annotation
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007338 single fertilization
GO:0007519 skeletal muscle tissue development
GO:0008344 adult locomotory behavior
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010468 regulation of gene expression
GO:0021520 spinal cord motor neuron cell fate specification
GO:0030326 embryonic limb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048704 embryonic skeletal system morphogenesis
GO:0048935 peripheral nervous system neuron development
GO:0050905 neuromuscular process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:96202
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28359
PhosphoSite PhosphoSite-P28359
TrEMBL
UniProt Splice Variant
Entrez Gene 15430
UniGene Mm.397433
RefSeq NP_038582
MGI ID
MGI Symbol Hoxd10
OMIM
CCDS CCDS16141
HPRD
IMGT
EMBL BC013463 BC048690 X14715 X62669
GenPept AAH13463 AAH48690 CAA44541 CAB57814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca