Mus musculus Gene: Hoxd10
Summary
InnateDB Gene IDBG-181043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxd10
Gene Name homeobox D10
Synonyms AI385591; AI874987; Hox-4.5; Hox-5.3;
Species Mus musculus
Ensembl Gene ENSMUSG00000050368
Encoded Proteins
homeobox D10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128710:
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm\'s tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74691924-74695105
Strand Forward strand
Band C3
Transcripts
ENSMUST00000061745 ENSMUSP00000062412
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007338 single fertilization
GO:0007519 skeletal muscle tissue development
GO:0008344 adult locomotory behavior
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010468 regulation of gene expression
GO:0021520 spinal cord motor neuron cell fate specification
GO:0030326 embryonic limb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048704 embryonic skeletal system morphogenesis
GO:0048935 peripheral nervous system neuron development
GO:0050905 neuromuscular process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P28359
TrEMBL
UniProt Splice Variant
Entrez Gene 15430
UniGene Mm.24420 Mm.397433
RefSeq NM_013554 XM_006498789
OMIM
CCDS CCDS16141
HPRD
IMGT
MGI ID MGI:96202
MGI Symbol Hoxd10
EMBL BC013463 BC048690 X14715 X62669
GenPept AAH13463 AAH48690 CAA44541 CAB57814
RNA Seq Atlas 15430