InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TACC1

Summary

InnateDB Protein

IDBP-18120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACC1

Protein Name

transforming, acidic coiled-coil containing protein 1

Synonyms

Ga55;

Species

Homo sapiens

Ensembl Protein

ENSP00000321703

InnateDB Gene

IDBG-18114 (TACC1)

Protein Structure

UniProt Annotation

Function

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.

Disease Associations

Tissue Specificity

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. {ECO:0000269PubMed:12165861, ECO:0000269PubMed:12547166}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0022027	interkinetic nuclear migration
GO:0032886	regulation of microtubule-based process
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0015630	microtubule cytoskeleton
GO:0045111	intermediate filament cytoskeleton