InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim33

Summary

InnateDB Protein

IDBP-181380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim33

Protein Name

tripartite motif-containing 33

Synonyms

8030451N04Rik; AI413936; Ecto; Tif1g;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029444

InnateDB Gene

IDBG-181378 (Trim33)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4- dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15314655, ECO:0000269PubMed:16751102}. Note=In discrete nuclear dots resembling nuclear bodies.

Disease Associations

Tissue Specificity

Ubiquitous with high level in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	9 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0070410	co-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016567	protein ubiquitination
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2137357

InterPro

IPR000315 Zinc finger, B-box
IPR001487 Bromodomain
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003649 B-box, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF00643
PF00439
PF13639
PF14634
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00336
SM00297
SM00184
SM00249
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt